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This protective effect is mediated through the activation of the Nrf2 pathway, which upregulates key antioxidant proteins, including GPX4, HO-1, TFR1, and FTH1, thereby mitigating ferroptosis (55)

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Manufacturers generally warn against using these drugs if a person has a personal or family history of medullary thyroid carcinoma, a type of thyroid cancer, or multiple endocrine neoplasia syndrome type 2 (MEN 2), an endocrine system condition

In future studies, it would be ideal to link NASH and type 2 diabetes separately to adverse CVEs incidence and mortality rate

People on blood pressure, ED, or psychiatric medications should review options with a clinician first

Given the vision-threatening concerns and widespread use of GLP-1RAs, some suggest candid patient conversations and closer follow-up may be warranted