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The main pathway for GLP-1 secretion is via cAMP signaling, and pasireotide inhibits GLP-1 secretion via SSTRs-Gi activation in GLUTag cells

doi:10.1016/s0300-483x(98)00144-9

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This process augments GS phosphorylation, thereby improving hepatic insulin sensitivity (Aurle et al., 2019

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