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Additionally, during early embryonic development, the methylation profile of the GAD1 gene becomes irregular, suggesting that epigenetic regulation may already be impaired during critical periods of neural development (40).Studies have shown that reduced expression of GAD65 or GAD67 in the central nervous system (CNS) can lead to ASD-like symptoms in mice

Evans SJ, Waller PC, Davis S

CI: confidence interval Figure 1: Time to First Occurrence of a MACE in Trial 7 Data from the in-trial period based on full analysis set defined as all randomized patients

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It also modulates the dopaminergic and serotonergic systems and increases NGF (Nerve Growth Factor) levels

Hormonal shifts around perimenopause and menopause can drive body composition changes, worsen insulin resistance, disturb sleep, and increase central fat storage