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Huperzine A: is it an effective disease-modifying drug for Alzheimer's disease

ROS and oxidatively modified macromolecules function as damage-associated molecular patterns (DAMPs), engaging pattern recognition receptors (PRRs) on microglia, including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), to initiate inflammatory cascades ( Microglia, the resident immune cells of the CNS, are tightly regulated under physiological conditions to maintain neural homeostasis

When this equilibrium is upset, either by chronic stress or pathological situations, it can result in the overproduction or underproduction of these hormones, which contributes to oxidative stress (50)

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Image: Peter Dazeley/Getty Images About the Author Marygrace Taylor, Health Writer About the Reviewer Pieter Cohen, MD, Contributor Disclaimer: As a service to our readers, Harvard Health Publishing provides access to our library of archived content