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Tirzepatide administration for 72 weeks elicited significant weight reduction ranging from 5% to 20.9% across different trials in a dose-dependent manner

How GLP-1 Therapy Works GLP-1 (glucagon-like peptide-1) receptor agonists and GLP-1/GIP are a class of medications originally developed to treat type 2 diabetes

At 1 year, vs controls: HbA1c 0.6% Time in range 7.5% Weight 13.4 kg Total daily insulin 29.9 units Systolic BP 12.6 mmHg Total cholesterol 0.8 mmol/L, triglycerides 0.7 mmol/L There was no between group difference in severe hypoglycemia, DKA, or hospitalization, and 89.4% were still on drug at 1 year

Liver injury induced by exposure to polystyrene microplastics alone or in combination with cadmium in mice is mediated by oxidative stress and apoptosis

Mol Biol Rep 2012

For tirzepatide specifically, some users report muscle pain , body aches , anxiety , and insomnia