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& Sheng, Z

Structure-based sequence alignment revealed several non-conserved residues between CCK1R and CCK2R in the SR146131-binding pocket, including the residues at the positions of 2.61, 6.51, 6.52, 7.27, and 7.39

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Observed effects in human trials Reported adverse events across the IV and oral trials included headache, fatigue, dizziness, nasopharyngitis, diarrhea, flatulence, increased appetite, nausea, and back pain

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This delicate regulatory mechanism highlights the essential role of SIRT1 in maintaining balance within complex cell signaling networks