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[10] [11] It is important to check folate status alongside B12, but folate supplementation should not be started before excluding B12 deficiency, as this may precipitate neurological complications

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When the liver is not functioning correctly, it can lead to a buildup of bile pigments in the blood, which are then excreted through the kidneys

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Also, those who have anemia or are vegetarian or vegan will want to consider a B12 regimen, as vegetable-based diets generally dont contain the amount of B12 that you need to thrive