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while an intervention study of smoking would not be feasible, a retrospective study of cigarette smoking in PD indicates no effect on the progression of established disease 58

Discussion We demonstrate for the first time that NAD + levels are depleted in both human and rat placentas affected by inflammation

These hybrids exhibited superior neuroprotective effects and lower cytotoxicity compared with curcumin alone, activated ARE, chelated ferrous ions and scavenged ROS, thereby protecting cells from oxidative stress and ferroptosis, ultimately promoting neuronal survival (104,127,128)

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