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Mechanisms of Action and Therapeutic Rationale Physiological Basis of GLP-1 Action GLP-1, an incretin hormone, plays a crucial role in glucose metabolism and appetite regulation, influencing insulin secretion, insulin-sensitivity, and gastric emptying [15] [16]

To generate knockout mutants of GSTF11 (AT3G03190) and GSTU20 (AT1G78370) based on the CRISPR-Cas9 system, the online website CRISPR-PLANT was used to design the gRNA spacer sequences ( Agrobacteria strain GV3101 and subjected to the floral dipping method

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