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By separating the lipolytic C-terminal region, researchers produced a compound with concentrated fat-metabolism activity and a significantly reduced side-effect profile compared to recombinant GH particularly with respect to insulin sensitivity and IGF-1 axis stimulation, which are primary concerns with full GH administration in research models

2, part B, pp

332 Furthermore, FOXO1 and Notch coordinately regulate gluconeogenesis by modulating G6PC expression

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