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The STEP trials purposely excluded individuals with a history of major depressive disorder (MDD), bipolar disorder, schizophrenia, or other significant mental illnesses as well as participants with past suicide attempts or who had experienced clinically significant suicidal thoughts

glutathione has no comparable monitoring requirement

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Due to 150 spontaneous reports to EMA regarding suicidal ideation [5] EMA and FDA have launched independent investigations into the potential risk of suicide and suicide attempts among users of GLP-1 RAs