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A clinical trial with DSIP

Over the years, methods have been refined into the most commonly used protocol today, which uses an acid/ethanol precipitation (to disrupt the IGF-1/IGFBP complex) followed by the addition of insulin-like growth factor-2 (IGF-2) to prevent the reformation of the IGF/IGFBP complex

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It stimulates collagen and elastin production, promotes wound healing, and possesses antioxidant and anti-inflammatory effects

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It is of interest to note that low AIP expression does not associate with resistance to pasireotide (61), the SS analog with the highest affinity for SSTR5, suggesting that AIP is not involved in the signal transduction of this specific SSTR subtype