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Patients taking antihypertensives (particularly diuretics, alpha-blockers, or nitrates) or SGLT2 inhibitors may experience additive effects on blood pressure or volume status when starting tirzepatide

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333 AG-270 is an oral selective MAT2A inhibitor that selectively inhibits the proliferation of MTAP null cells and effectively reduces the level of SAM in tumor cells in tissue and xenograft tumor models

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For hypothyroid patients, this means potentially even larger levothyroxine dose adjustments would be needed

D.LaskoP.et al (2005)