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10, e01013

The analyses were conducted with multiple imputation of missing values at week 48 and statistical inference over multiple imputation of missing data guided by Rubin 33

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Whether those effects survive the scrutiny of trials like TAG-MS, the ongoing Parkinsons studies, and the next wave of Alzheimers prevention work will determine whether the brain-volume question becomes a clinical recommendation or remains a tantalizing observational signal

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