A pre- in vitro maturation medium containing cumulus oocyte complex ligand-receptor signaling molecules maintains meiotic arrest, supports the cumulus oocyte complex and improves oocyte developmental competence
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Other concerning features that warrant prompt medical attention include: new headache onset after age 50, headache during pregnancy or postpartum period, headache with fever or neck stiffness, headache following head trauma, headache in immunocompromised patients, and headache that worsens with position changes or Valsalva maneuver (coughing, straining)