Injections provide consistent dosing, especially when absorption may be an issue
In humans, kidney removes 68 U of insulin per day by two major routes (Figure 2), that apparently have distinct preferential physiological goals: post-glomerular secretion (insulin signaling) and glomerular filtration (nutrient conservation and homeostasis) (Ritz et al., 2013)
Why we need proper PBPK models to examine intestine and liver oral drug absorption
Also, simplified MMH can reduce the damage of MMH to anal cushions, protect dentate line and reduce the incidence of anorectal complications
Accessed September 28, 2019
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