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This pharmacological profile contributes to its off-label use in managing conditions like anxiety, depression augmentation, and binge eating disorder FDA-Approved and Off-Label Uses FDA-Approved Use: Attention-Deficit/Hyperactivity Disorder (ADHD) in children (age 6+), adolescents, and adults Off-Label Uses: Generalized Anxiety Disorder (GAD) Treatment-resistant depression (as augmentation) Binge Eating Disorder (BED) Obsessive-Compulsive Disorder (OCD) Executive dysfunction in autism spectrum disorders Always consult a licensed medical provider for off-label usage

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Conclusions In sum, the findings illustrate that adding bupropion/naltrexone therapy to GLP-1 analog monotherapy results in additional weight loss, even in those with an initially poor response to the monotherapy

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