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These synthetic peptides differ in amino acid sequence and biologic properties.I3 In our previous studies, we demonstrated that injection of thymosin a', thymopentin, or THF-y2 into aging mice can increase T-cell functions when spleen cells were tested in vitro for T helper cell activity, proliferative responses to T-cell mitogens, cytokine production, and expression of cytokine receptors

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Antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice forced swim test

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However, a crucial limitation of the above studies is that the endpoint was pathologic (described as asymptomatic chronic pancreatitis), referring to histologic changes, rather than clinical 26

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