Research shows low-load BFR training can drive tendon adaptations comparable to high-load training: 14 weeks ~8% cross-sectional area & ~36% stiffness (Centner et al., 2019) Short-term pain relief (~45 min) enabling loading when it otherwise hurts (Korakakis et al., 2018) This means athletes and patients can achieve meaningful tendon stimulus and pain relief without high mechanical stress
Genetic testing is used to see if a person has the genetic variants that cause mEDS
Metformin, widely prescribed for type 2 diabetes, can impair B12 absorption through effects on calcium-dependent ileal uptake
[DOI] [PubMed] [Google Scholar] 218.Zhang L., Dawson V.L., Dawson T.M
Older adults are at a higher risk for B12 deficiency for a number of reasons: Digestive issues that interfere with absorption Reduced food intake Dental issues that discourage meat consumption Disturbances to the gut biome Excess alcohol consumption Reduced stomach acid production that lowers absorption Reduced consumption and absorption of B12 can lead to neurological disorders, cognitive impairment and a number of other issues that accelerate aging and reduce overall quality of life
MOTS-c activates AMPK by disrupting the folate cycle, specifically by inhibiting AICAR transformylase, an enzyme in the de novo purine synthesis pathway
