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9 surprising reasons youre not losing weight You're Not Yet on a Therapeutic Dose One of the most common reasons a GLP-1 appears ineffective is that you're still in the dose-escalation phase
McAninch EA, Fonseca TL, Poggioli R, Panos AL, Salerno TA, Deng Y, et al
A recent study found that the triple agonist retatrutide for GLP-1R, GIPR and GCGR substantially induced weight loss in obese adults, demonstrating the clinical potential of this triple agonist for obesity treatment
Since, studies have attempted to elucidate the mechanisms governing this reduction and further identify the clinical utility of GLP-1RAs, but much must be inferred from preclinical studies in diabetic models
Cost concerns also play a role