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A double-blind trial published in the Journal of Cosmetic Dermatology found that topical GHK-Cu at 3% concentration applied twice daily for 12 weeks increased skin elasticity by 27% and reduced fine-line depth by 35% compared to vehicle control

It is one of the 13 members of the SLC22 family that includes organic cation transporters (OCTs), organic zwitterion/cation transporters novel (OCTNs), and organic anion transporters (OATs)

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36,38,237,238,239 The E-boxes in the promoter of Nampt gene allow the direct transcriptional control by the CLOCK: BMAL1 chromatin complex