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In the SURMOUNT-1 tirzepatide program, lean mass again made up a minority of total loss with fat mass falling more ( Jastreboff et al., NEJM 2022 )

For context, semaglutide manages roughly 15% and tirzepatide reaches about 22.5% in their respective trials

Cholesterol and lipid improvements: rewriting your lipid panel High cholesterol and dyslipidemia contribute massively to cardiovascular disease risk

Careful baseline cardiovascular assessmentincluding EKG, blood pressure monitoring, and heart rateis non-negotiable

We also translate the cardiovascular story into human termswhy some large trials found fewer heart attacks and strokes and give a reality-check on the brain research so you know whats hopeful and whats hype

This is the first trial directly comparing retatrutide and tirzepatide in 800 patients under identical conditions