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People with a history of pancreatitis, gallbladder disease, kidney problems, diabetic retinopathy, or complex medication needs should discuss those details before treatment begins

This means it increases the amount of serotonin and norepinephrine available in the brain, which may reduce the transmission of pain signals from the brain, and provide relief from musculoskeletal pain

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In addition, Shao et al

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It does not yet provide long-term cardiovascular outcome data or real-world effectiveness outside controlled trial conditions