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Results: There were 594 upregulated and 90 downregulated proteins identified in the semaglutide cohort compared with control cohort

doi: 10.1056/NEJMoa1411892, [DOI] [PubMed] [Google Scholar] Plamboeck A., Veedfald S., Deacon C

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2025: Novo Nordisk announced positive Phase 3 ESSENCE trial results for semaglutide in early Alzheimer's disease, reporting statistically significant slowing of cognitive and functional decline a breakthrough data package that could establish GLP-1 therapy as a neuroprotective agent and open an addressable market of 6.5 million Alzheimer's patients in the U.S

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