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Apparently, Trp 33 is accessible for binding of both small and large molecules which is interesting considering the spatial relationship between the ECD and TM domain of GLP-1R

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Philos Trans R Soc Lond B Biol Sci (2013) 368(1615):20110375.10.1098/rstb.2011.0375 203 MosienkoVBertBBeisDMatthesSFinkHBaderMet alExaggerated aggression and decreased anxiety in mice deficient in brain serotonin