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The deleterious effect of NO is observed once it reacts with superoxide anion, generating exceedingly reactive peroxynitrite anion (ONOO)

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Sedating antihistamines (chlorphenamine, promethazine) can cause CNS depression that masks stimulant benefits and may worsen apparent ADHD symptoms

A meta-analysis of 31 publications (11,816 strokes) revealed a 49% increase of occurrence between 0600 and 1200 h in all types of strokes, and 79% increase over normalized risk compared to the other 18 h of the day (Elliott, 1998), with the lowest incidence of stroke reported between 0000 and 0600 h (Elliott, 1998)

doi: 10.1016/j.toxicon.2012.07.169 53 CiryamP.Lambert-SmithI

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