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The copper ion confers catalytic activity: GHK acts as a copper chaperone, delivering Cu to cuproenzymes including superoxide dismutase 1 (SOD1), cytochrome c oxidase (Complex IV), lysyl oxidase (LOX), and ceruloplasmin

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The high prevalence among carriers likely reflects their age ( 55 years), which corresponds to the typical onset window for TTR-V30M amyloidosis in Sweden