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10.1016/j.chemosphere.2017.05.030 64
Inhibit osteoclast activation and differentiation, reduce bone resorption Block osteoclast differentiation signal RANKL/RANK/OPG pathway: AOD 9604 downregulates the expression of RANKL (a key factor in osteoclast differentiation) and upregulates the expression of OPG (a RANKL antagonist), reducing the RANKL/OPG ratio by 50-60% and blocking the differentiation of osteoclast precursors into mature osteoclasts
To reconstitute tirzepatide: draw bacteriostatic water into a syringe, inject it slowly against the glass wall of the peptide vial, and swirl gently until the powder dissolves
[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Gardner S, et al
Fang Y, You J, Xie K, Xie W, Xiong L
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