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When delivered via microneedling, they bypass the barrier entirely and reach the follicle directly

\Targeted Delivery: May distribute throughout the body and concentrate at sites of injury where repair cells are needed

Self-reported community protocols commonly describe once-daily dosing with on/off cycling, motivated partly by the absence of any long-term human safety data and partly by a community perception of diminishing returns or tolerance over continued use

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Underground forums report anecdotal side effects including joint pain, injection site reactions, and fatigue, though causality is unclear