Retatrutide is administered once weekly
The FDA has approved its use for chronic weight management in adults with a body mass index (BMI) of 30 or more, or a BMI of 27 or more when accompanied by at least one weight-related condition such as high blood pressure, high cholesterol, or type 2 diabetes
This class of compounds binds to key receptors in the brain, pancreas, and gastrointestinal (GI) tract, instigating several biological reactions: Enhances insulin secretion Slows gastric emptying Increases -cell proliferation Reduces glucagon release Mitigates hunger signaling These actions combine to regulate appetite, food intake, and the physical feeling of fullness (satiety)
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Nearly a month after she was diagnosed with an overdose, McClain said she was still dealing with the residual side effects, including an elevated heart rate and vision problems she felt were tied to the medication
But researchers generally agree that the drug harnesses the brains GLP-1 receptors to curb food intake
