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Gerber P, Anderin C, Thorell A

While Saxenda is only approved for obese patients with a body mass index of 35 or higher, Wegovy is recommended for people with a BMI over 30

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To stimulate lipolysis and energy-balance pathways in adipocyte, muscle, and liver models

This is an especially important approach in the MGD space, because the ubiquitin ligaseMGD neosurface (rather than the compound alone) determines which neosubstrate surfaces bind and how these proteins are presented to ubiquitylation active sites 12

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