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It was also found that 968 was capable of reversing adriamycin resistance in MCF-7/ADR, a drug-resistant cell line of BC, in a time- and drug-concentration-dependent manner [145]

J Clin Invest , 1988

Clinical trials show moderate-to-large effects (e.g., 25-35% wrinkle/scar improvements), though limited by sample sizes and short durations

In the same trial, people on CagriSema lost an average of about 23% of their body weight over 68 weeks when measuring the effect assuming full adherence, or about 21% when accounting for all participants regardless of whether they completed treatment

188 Germline GOF-heterozygous variants have also been reported in the TP53 gene

The real answer is both are effective, but together they work even better