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Effect of Sodium-Glucose Cotransporter-2 Inhibitors on Aldosterone-to-Renin Ratio in Diabetic Patients With Hypertension: A Retrospective Observational Study
GLP-1 medications are synthetic versions designed to activate these same pathways more powerfully and persistently
Addressing Barriers and Concerns Several barriers prevent more psychiatrists from prescribing GLP-1 medications
This way of doing things is good for people who have ongoing issues like type 2 diabetes
For now, the main considerations remain absorption, appetite, and vital signsbut keep an eye on this space as more evidence develops
Goal: Type 2 diabetes management (A1C reduction) If you prefer once-weekly injections: Semaglutide (Ozempic), tirzepatide (Mounjaro), dulaglutide (Trulicity), or efpeglenatide (Eperzan) If you prefer daily injections: Liraglutide (Victoza) or lixisenatide (Adlyxin) If you prefer oral medication: Semaglutide (Rybelsus) If cost is the primary concern: Compounded semaglutide or compounded tirzepatide (if eligible under shortage provisions) Goal: Weight loss (obesity or overweight with comorbidities) If you want maximum weight loss: Retatrutide (Retara, triple agonist, 24% mean loss) or tirzepatide (Zepbound, dual agonist, 20% to 22% mean loss) If you want proven long-term safety data: Semaglutide (Wegovy, 15% to 17% mean loss, 5+ years post-approval data) If you prefer oral medication: Orforglipron (Orfoglip, 15% mean loss, oral once daily) If cost is the primary concern: Compounded semaglutide or compounded tirzepatide Goal: Both diabetes and weight loss If you have significant obesity (BMI over 35): Tirzepatide (Mounjaro for diabetes indication, Zepbound for obesity indication
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