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The STEP 1 trial showed participants using semaglutide lost an average of 14.9% of their body weight over 68 weeks

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Liraglutide also increased the expression of VSMC contractile markers such as -smooth muscle actin (-SMA), smooth muscle myosin heavy chain 11 (MYH11), and myocardin [54]

Gastrointestinal side effects may induce fatigue Gastrointestinal issues like nausea and diarrhea are more common Wegovy side effects than fatigue

Monitoring for Absorption Issues: While not a common issue, laxatives, particularly those that work quickly or alter gut motility significantly, could theoretically affect the absorption rate of other medications

Many patients find that working with a compounding pharmacy allows greater flexibility in adjusting doses during transition phases compared to brand-name alternatives