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Substance use disorders An emerging area of interest for GLP-1RAs is their potential role in the treatment of substance use disorders, including alcohol and nicotine dependence.[51] GLP-1 is endogenously produced in the nucleus tractus solitarius of the brainstem and acts as a neuropeptide modulating reward and addiction pathways.[52, 53] GLP-1 receptors are expressed in key regions involved in reinforcement, including the ventral tegmental area and nucleus accumbens, where they modulate glutamatergic signaling, potentially influencing feeding and substance-related behaviors.[53, 54] Though ongoing trials are actively investigating the role of GLP-1RAs in substance use disorders, the current evidence base is constrained by a small number of studies, limited randomized controlled trials, heterogeneity in agents evaluated, and variability in outcome measures.[55] One cohort study of U.S
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It is important to work with a healthcare provider to determine the best GLP-1 medication for individual needs and goals
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