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A placebo controlled randomized clinical trial of Crocus sativus L.(saffron) on depression and food craving among overweight women with mild to moderate depression

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Some people may notice a slight decrease in hunger or smaller portion sizes, but significant weight changes are not typical at this early stage

According to the same survey, Awareness of GLP-1 drugs has increased in the past year, with about one-third (32%) of adults now saying they have heard a lot about these drugs, up from 19% in July 2023. Fifty-four percent of people who took a GLP drug said it was difficult to afford and it is often reported that, although doctors recommend staying on these drugs for a lifetime, many abandon them after a year

Additionally, preclinical research suggests GLP-1 receptors may be present in various tissues beyond the pancreas and brain, including synovial tissue and chondrocytes

However, most of the subjects included in the RCTs are PCOS patients with obesity/overweight, whereas a portion of PCOS women, which can even reach 50%, might present a lean phenotype