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Compared to the control, T2DM patients treated with semaglutide 1 mg saw a reduction of 29 mg/dL (22%) for pre-prandial glucose, 74 mg/dL (36%) for 2-h postprandial glucose, and 30 mg/dL (22%) for mean 24-h glucose concentration [26]

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Ascorbic acid protects against endogenous oxidative DNA damage in human sperm

46 Thus, pharmacological inhibitors, blocking antibodies and knockdown of PI3K abolishes the insulin stimulation of glucose transport, GLUT4 translocation and DNA synthesis

Recent studies indicate that natural compounds (e.g., resveratrol, curcumin) improve gut-liver barrier function through microbiotaSIRT1 interactions, while synthetic activators (SRT1720) and NAD + precursors (NMN) enhance hepatocyte antioxidant capacity and fatty acid -oxidation

Mitochondrial dysfunction plays a key role in the occurrence and development of skeletal muscle atrophy mainly through the molecular mechanism mediated by this signaling axis [35]