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Ischemia and hypoxia can disrupt the microbial composition of the gut microbiome, which can lead to intestinal barrier dysfunction and bacterial translocation [12]

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Co-administration of MB with any of these can lead to an acute surge in serotonin signaling in the central nervous system, manifesting as agitation, confusion, high fever, sweating, muscle rigidity or tremors, and potentially seizures or cardiovascular collapse

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