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Retention of this excess cytoplasm has been associated with the existence of oxidative stress in the germ line in several independent studies [27, 28]

Available from: Faras C, Cisternas C, Caicedo A, Mercado L, Valenzuela R, Caldern H, et al

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doi: 10.1016/S0140-6736(82)91330-7 78 CappadoroMGiribaldiGOBrienETurriniFMannuFUlliersDet al

Validation studies have been conducted in many countries, with proposed cutoff values ranging from 10 to 22 [104,105,106,107,108,109,110]