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275 PrP Sc and other prion-like polypepetides have the interesting properties of being infectious and able to induce the generation of more prion particles when seeded from one CNS region to another or from even from one individual to another either by ingestion via the diet, or via implantation into the CNS for example from surgical instruments or tissue grafts

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Insulin signaling also regulates protein abundance through transcriptional or translational regulation, including the expression of glucokinase (Gck) and phosphoenolpyruvate carboxykinase 1 (Pck1) 15,16