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Its a methodological necessity

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[DOI] [PMC free article] [PubMed] [Google Scholar] 74.Gojkovic S., Krezic I., Vranes H., Zizek H., Drmic D., Pavlov K.H., Petrovic A., Batelja L., Milavic M., Sikiric S., et al

found that magnesium ions (Mg 2+ ) promote the synthesis of cartilage matrix mediated by hypoxia inducible factor-1 (HIF-1) (Yao et al., 2019)