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Activation of NCX and sodium/hydrogen exchanger-1 (NHE-1), at cardiac and vascular level, mediate the maladaptive neurohormonal stimulation (sympathetic nervous system, RAAS, and natriuretic peptide system) during the pathophysiological course toward HF (Baartscheer et al., 2003

Studies have shown that this epithelial damage is in part due to the inability to mitigate reactive oxygen species (ROS)

The trade-off is three separate reconstitutions instead of one

The first oral candidate(s) could be approved on weight-loss efficacy below pens but with convenience and adherence upside

Diabetes Care 46 (1), 209221