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The linker region of the nucleosome comprises a complex of 60 base pairs of DNA and histone H1 (Hao et al., 2021)

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FIGURE 8 FIGURE 9 In good agreement with this observation, a simple accumulation of Nrf2 is not sufficient for the development of spontaneous cancers (Taguchi et al., 2010), although a large number of human cancers depend on Nrf2 activity

On the other hand, in terms of weight loss, available data suggest that the combination of the 2 agonists had a synergistic effect (table 1) [10]