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investigated the renal effects of a 3-day rhIGF-1 treatment (100 g/kg twice daily) in 4 adult patients with advanced CKD (GFR 2155 ml/min/1.73 m 2 ) showing significant increases of both GFR and RPF in all patients, which was associated with a small increase in kidney size [176]
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However, under pathophysiological conditions, especially during APAP overdose, excessive NAPQI accumulates and binds to cellular proteins, also triggering oxidative stress, leading to hepatocellular damage and the release of damage-associated molecular patterns (DAMPs), contributing to further liver injury and inflammation
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& Foitzik, K
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