This leads to significant tumor cytotoxicity, ischemia, and hypoxia, while simultaneously inhibiting the proliferation of tumor cells and killing them
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This activation of IRTK results in the activation of insulin receptor substrate (IRS), growth factor receptor-bound protein (GRB) 2, GRB10, and SHC, which are phosphotyrosine binding proteins [7], which are known to play critical regulatory roles
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