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Up to now, powerful genetic tools allowed clarification of the significance, dispensability and potential of cystine transporters for ferroptotic cell death in PDAC and breast cancer ( via xCT ( A high extracellular glutamate concentration was one of the first xCT inhibitors described but a few years later, erastin (standing for eradicator of RAS and small T antigen-expressing cells) was identified by Stockwell's group in RAS-mutated cancer cell lines as inhibitor of xCT transport ( in vitro studies as efficient inducer of ferroptosis in many different cancer types, including breast, PDAC, lymphoma, renal, brain and ovarian cancers ( via transsulfuration pathway is a potential resistance mechanism under cysteine depletion conditions

Photon energy changes brought about by laser light interaction with a sample reveal details on the vibrational states of the molecules

Amylin analogs are challenging to manufacture because amylin is notoriously aggregation-prone, requiring specific amino-acid substitutions and synthesis controls

When you take it on an empty stomach, your body can absorb it more easily

Here we provide an example of how plant parasites of global economic importance have populated their effector repertoire by the unprecedented duplication and subsequent re-deployment of the endogenous housekeeping gene, glutathione synthetase

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