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The safety profile was largely in line with established GLP-1based therapies, with gastrointestinal events being the most common and generally manageable

For adults over 40, the maintenance phase is not a passive thing it requires conscious decisions about whether to stay on a maintenance dose, taper down, or come off entirely

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In addition, questions remain about the impact of GLP-1R signaling on immune cell biology and the precise role of GLP-1RAs in various autoimmune and autoinflammatory conditions

Every study showing results was done alongside diet and exercise