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The choice between them may ultimately depend on clinical indication: retatrutide for maximum weight loss and metabolic improvement, survodutide for MASH-focused treatment where it has the most advanced regulatory pathway

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This regimen did not lead to an increase in tumor formation in mice that received both treatments compared to mice that received azoxymethane alone

Importantly, serum glucagon levels were significantly lower in AAV-sh-VGF-injected mice compared to controls (Fig