Long-Term Considerations Weight Regain After Discontinuation Both medications are associated with weight regain after discontinuation: STEP 1 extension data showed that participants who stopped semaglutide regained approximately two-thirds of their lost weight over the following year (Wilding et al., Diabetes, Obesity and Metabolism , 2022) Long-term data for tesofensine is more limited, but weight regain is expected given that the appetite-suppressing mechanism ceases when the medication is stopped This underscores the importance of viewing these medications as long-term or indefinite treatments for chronic obesity management, rather than short-term interventions
Why Mental Health Is Now Part of the GLP-1 Conversation When GLP-1 medications first entered widespread use, their effects were viewed mainly through a metabolic lens
Keep medications away from direct contact with the freezer compartment to prevent accidental freezing
Even though DKA is rare in people using Semaglutide, any strong fruity odor in the urine combined with other symptoms should be taken seriously
Excessive drinking, or 15+ weekly drinks for men / 8+ for women, is a no-go on semaglutide, and is something you should avoid even if you arent
Generally, the older you get, the more likely you are to develop tendon issues
