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If liver fat reduction is a key objective, retatrutide offers substantially greater hepatic fat clearance than tirzepatide, as discussed above

Lilly touts that, in clinical trials, orforglipron was taken once a day at any time, without restrictions on food or water

Safety matters just as much

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Mechanism Although the biological rationale for GLP-1 RA-induced biliary toxicity is not clear, the current findings indicate potential weight-loss-dependent mechanisms

Less common side effects included skin tingling and increased heart rate for up to 24 weeks, after which time heart rate declined